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Bravecto For Large Dogs (20-40kg)

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R 450,00

Product Info

Bravecto For Large Dogs between 20kg and 40kg
-Fast acting - within 2 hours of dosing
-Protects for 12 weeks
-Unaffected by swimming and shampooing
-Safe for pregnant and lactating bitches
-Safe for puppies from 8 weeks of age
Manufacturer:

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Indications

For the treatment and prevention of tick, flea and mite infestations in dogs. Bravecto® kills adult, as well as juvenile ticks (larvae and nymphs). Bravecto® can be used as part of a treatment strategy for Flea Allergy Dermatitis (FAD). For the treatment of Demodicosis caused by Demodex spp. and Sarcoptic mange mites. In a controlled trial, treatment with fluralaner resulted in the complete removal of Demodex spp. mites from treated dogs. For the treatment of Otodectes spp. (ear mite) mite infestations.

Composition

Contains fluralaner equivalent to 25 to 56 mg/kg body weight.

Each chewable tablet contains:

  • Miniature Dogs: 112,5 mg
  • Small Dogs: 250 mg
  • Medium Dogs: 500 mg
  • Large Dogs: 1 000 mg
  • Extra-Large Dogs: 1 400 mg

Pharmacodynamic properties

Fluralaner is an acaricide and insecticide. It is efficacious against ticks (Ixodes spp., Dermacentor spp. , and Rhipicephalus sanguineus) and fleas (Ctenocephalides spp.) on the dog. Fluralaner is systemically active on target parasites. Contact activity against ticks and fleas is of minor relevance. Fluralaner is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate-receptor). In a molecular on target study, Fluralaner is not affected by dieldrin resistance. In vitro, Fluralaner overcomes resistance against amidines, organophosphates, cyclodienes, macrocyclic lactones, phenylpyrazoles, benzophenyl ureas, pyrethroids and carbamates. In vivo, Fluralaner is highly effective against fleas proven to be less susceptible to phenylpyrazole insecticides.

Pharmacokinetic particulars

Following oral administration, Fluralaner is readily absorbed reaching maximum plasma concentrations within one day. Food enhances the absorption. Fluralaner is systemically distributed and reaches the highest concentrations in the visceral fat, followed by liver, kidney and muscle. The prolonged persistence and slow elimination from plasma (t½ = 12 days) and the lack of extensive metabolism provide effective concentrations of Fluralaner for the duration of the inter-dosing interval, ensuring efficacy for 12 weeks. The major route of elimination is the excretion of unchanged Fluralaner in faeces (~90 % of the dose). Renal clearance is the minor route of elimination.

Warnings

  • Use with caution in dogs with pre-existing epilepsy.
  • Safety in puppies less than 8 weeks of age and/or dogs weighing less than 2 kg has not been established.
  • Keep the product in the original packaging until use.
  • Do not use in case of hypersensitivity to fluralaner or to any of the excipients.
  • KEEP OUT OF REACH OF CHILDREN, UNINFORMED PERSONS AND ANIMALS.
  • Can be used in breeding, pregnant and lactating dogs.
  • Bravecto® is well tolerated in MDR1 dogs following oral administration.

Although this remedy has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder.

Precautions:

  • Do not eat, drink or smoke while handling the product.
  • Wash hands thoroughly with soap and water immediately after use of the product.
  • Do not store with food, drinks, medication or household products.

Directions Of Use - Use ONLY As Directed

  • Administer tablets at or around the time of feeding for maximum effectiveness.
  • It can be mixed with food or given by hand since it is very palatable.
  • For optimal control of tick and flea infestation, BRAVECTO® should be administered at intervals of 12 weeks.
  • BRAVECTO® can be administered all year round.

Dosage:

Weight In kg Size Of Tablet

  • 2-4.5 / 112,5 mg for miniature dogs
  • 4,5 - 10 / 250 mg for small dogs
  • 10 – 20 / 500 mg for medium dogs
  • 20 – 40 / 1000 mg for large dogs
  • 40 - 56 / 1400 mg for x-large dogs
  • Within each weight range a whole tablet must be used.

For dogs more than 56 kg, use a combination of two tablets that most closely matches the body weight.

Overdose

BRAVECTO® was well tolerated following oral administration to puppies aged 8 - 9 weeks and weighing 2,0 - 3,6 kg at doses of up to 56, 168 and 280 mg Fluralaner/kg body weight (equivalent to 1, 3 and 5 times the maximum expected clinical dose) on 3 occasions at 8-week intervals. No treatment-related adverse effects were observed.

There were no findings on reproductive performance and offspring viability when up to 168 mg/kg of Fluralaner (equivalent to 3 times the maximum treatment dose) was administered orally to Beagle dogs.

Efficacy

BRAVECTO® was shown to be effective* against fleas and various tick species.

* Efficacy > 90 - 95 %

BRAVECTO® is indicated for the treatment of the following:

Ticks:(Ixodes ricinus, Ixodes hexagonus, Ixodus scapularis, Dermacentor reticulatus, Dermacentor variabilis and Rhipicephalus sanguineus)

Directly after treatment, at least 90 % of ticks on the dog are killed within 8 hours. During the whole treatment interval, at least 90 % of ticks on dogs are killed within 12 hours.

Fleas:Ctenocephalides felis

Directly after treatment, at least 95 % of fleas are killed within 8 hours. During the whole treatment interval, at least 95 % of fleas on dogs are killed within 12 hours.

Effect on immature stages

The product kills adult as well as juvenile ticks (larvae, nymphs). Newly emerged fleas on a dog are killed before viable eggs are produced. An in vitro study also demonstrated that very low concentrations of Fluralaner stop the production of viable eggs by fleas.

Control of Flea Infestations and Flea Allergy Dermatitis (FAD)

The flea life cycle is broken due to the rapid onset action and long lasting efficacy against adult fleas on the animal and the absence of viable egg production. BRAVECTO® effectively controls environmental flea populations in areas to which the dog has access. BRAVECTO® can be used as part of a treatment strategy for flea allergy dermatitis (FAD).

Presentation

Light to dark brown chewable tablet with a smooth or slightly rough surface and circular shape. Some marbling, speckles or both may be visible. Packaged in aluminium foil blister with aluminium foil lid stock.

How Does Bravecto Work?

 

20 customer reviews

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2 ratings
5 days ago
Review
Like a dream!
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0 of 0 people found the following review helpful
3 ratings
24 days ago
Review
I'm a first time Bravecto user and I honesty couldn't be happier. I have tried the spot on for my cats and a spot on for my more "fussy" dog as I was sure she wouldn't eat the tablet as she is known to even turn down some left over chicken! about an hour and a bit after dosing I started to see the ticks and fleas falling off her, absolutely no negative side effects to report either.
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0 of 0 people found the following review helpful
2 ratings
1 month ago
Review
Works well, convenient once every three months dosing. Works out cheaper than some of the other alternatives and works better.
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0 of 0 people found the following review helpful
2 ratings
1 month ago
Review
My dog has a bad case of the fleas, rash on it stomach and losing hair from her tail. No other flea control worked. So my vet recommended bravecto. i used it and within 24 hrs the fleas were gone, after a few days the rash was clearing up and hair was starting to grow back. ive been using this tablet for my dog for 2 years now. Best thing ever.
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0 of 0 people found the following review helpful
3 ratings
1 month ago
Review
Best tick and flea product ever no question.
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0 of 0 people found the following review helpful
2 ratings
2 months ago
Review
Nothing beats Bravecto.
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0 of 0 people found the following review helpful
4 ratings
2 months ago
Review
I swear my dogs look forward to getting their Bravecto every 3 months lol, as soon as they come out of the box they are sitting there waiting for their treats.
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0 of 0 people found the following review helpful
4 ratings
2 helpful voted.
2 months ago
Review
Bravecto is without a doubt the best tick and flea product that we have ever used.
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0 of 0 people found the following review helpful
1 rating
2 months ago
Review
I honestly agree with all of the previous reviews. I have never had any issues with Bravecto and we have been using it on all of our dogs for the last few years and have never had a negative experience.
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0 of 0 people found the following review helpful
3 ratings
2 months ago
Review
Super easy to dose, Dogs love the taste and I’ve had 0 tick and flea issues on my 3 Danes for the last 3 years.
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0 of 0 people found the following review helpful